34. Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes
Freshman Organic Chemistry (CHEM 125)
Professor Barry Sharpless of Scripps describes the Nobel prize-winning development of titanium-based catalysts for stereoselective oxidation, the mechanism of their reactions, and their use in preparing esomeprazole. Conformational energy of cyclic alkanes illustrates the use of molecular mechanics.
00:00 - Chapter 1. Introduction for Professor Barry Sharpless
02:52 - Chapter 2. The Reactivity of Allyic Alcohols and Vanadium-Catalyzed Epoxidations
11:44 - Chapter 3. Research with Katsuki and the Discovery of Combining Titanium with Tartaric Acid
21:10 - Chapter 4. The Mechanism for Asymmetric Epoxidation of Olefins and the Story of Nexium
41:05 - Chapter 5. The Conformation of Rings: Carvone and Cyclohexane
Complete course materials are available at the Open Yale Courses website: http://open.yale.edu/courses
This course was recorded in Fall 2008.